Respiratory function of mitochondria is compromised in aging human tissues and severely
impaired in the patients with mitochondrial disease. A wide spectrum of mitochondrial DNA …

Accumulation of somatic mutations in the mitochondrial DNA (mtDNA) is a major contributor
to human aging and degenerative diseases. Rapid progress has been made in unraveling …

In the aging process, mitochondrial function gradually declines with an increase of mutations
in mitochondrial DNA (mtDNA) in tissue cells. Some of the aging-associated mtDNA …

Mitochondrial respiratory function is impaired in the target tissues of patients with
mitochondrial diseases and declines with age in various human tissues. It is generally …

The mitochondrial respiratory system is the major intracellular source of the reactive oxygen
species (ROS) and free radicals, which are generated as byproducts during the transfer of …

Mitochondria are the major intracellular source and target sites of reactive oxygen species
(ROS) that are continually generated as by-products of aerobic metabolism in animal and …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

Aging is a biological process that is characterized by the gradual loss of physiological
function and increases in the susceptibility to disease of an individual. During the aging …

Human mitochondrial DNA (mtDNA) is a multi-copy extra-chromosomal genetic element,
which is exposed to a high steady-state level of reactive oxygen species and free radicals …

Aging is a degenerative process that is associated with progressive accumulation of
deleterious changes with time, reduction of physiological function and increase in the …