Aquaporin-5 expression, trafficking, and interacting partners in the bovine lens

RB Gletten - 2022 - search.proquest.com
Abstract Aquaporin-5 (AQP5) regulates osmotic balance and transparency of the ocular lens
through facilitated diffusion of water and represents an integral component of the lens …

Lens aquaporin-5 inserts into bovine fiber cell plasma membranes through mitochondria-associated lysosome secretion

RB Gletten, LS Cantrell, S Bhattacharya, KL Schey - bioRxiv, 2022 - biorxiv.org
PURPOSE To spatially map aquaporin-5 (AQP5) expression in bovine lens, molecularly
characterize cytoplasmic AQP5-containing vesicles in the outer cortex, and elucidate AQP5 …

[HTML][HTML] Lens aquaporin-5 inserts into bovine fiber cell plasma membranes via unconventional protein secretion

RB Gletten, LS Cantrell… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: To spatially map aquaporin-5 (AQP5) expression in the bovine lens, molecularly
characterize cytoplasmic AQP5-containing vesicles in the outer cortex, and elucidate AQP5 …

Verification and spatial localization of aquaporin-5 in the ocular lens

AC Grey, KL Walker, RS Petrova, J Han… - Experimental eye …, 2013 - Elsevier
Until recently, the lens was thought to express only two aquaporin (AQP) water channels,
AQP1 and AQP0. In this study we confirm lenticular AQP5 protein expression by Western …

[HTML][HTML] The role of aquaporins in ocular lens homeostasis

KL Schey, RS Petrova, RB Gletten… - International journal of …, 2017 - mdpi.com
Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens
homeostasis, contribute to the establishment and maintenance of the overall optical …

[HTML][HTML] Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A

SS Kumari, M Varadaraj, VS Yerramilli… - Molecular …, 2012 - ncbi.nlm.nih.gov
Purpose Aquaporins (AQPs) play a significant role in the movement of water across the
plasma membrane. In the eye, the cornea and lens are avascular with unique …

Mechanism of AQP5 trafficking in lens fiber cells

KL Schey, RB Gletten - Investigative Ophthalmology & Visual …, 2022 - iovs.arvojournals.org
Purpose: Aquaporin-5 (AQP5) is the second most abundant aquaporin in ocular lens fiber
cells and its localization and thus fiber cell permeability can be regulated. Previously we …

[HTML][HTML] Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency

SS Kumari, S Eswaramoorthy, RT Mathias… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Aquaporin (AQP) 1 and AQP0 water channels are expressed in lens epithelial and fiber
cells, respectively, facilitating fluid circulation for nourishing the avascular lens to maintain …

Spatial distributions of AQP5 and AQP0 in embryonic and postnatal mouse lens development

RS Petrova, KL Schey, PJ Donaldson… - Experimental eye …, 2015 - Elsevier
The expression of the water channel protein aquaporin (AQP)-5 in adult rodent and human
lenses was recently reported using immunohistochemistry, molecular biology, and mass …

Intact AQP0 performs cell-to-cell adhesion

SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2009 - Elsevier
Aquaporins (AQPs) constitute a major conduit for movement of water across plasma
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …