Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

The prodrug concept has been used to improve undesirable properties of drugs since the
late 19th century, although it was only at the end of the 1950s that the actual term prodrug …

Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that
require a transformation within the body in order to release the active drug. They are …

Prodrugs offer a versatile strategy to overcome flaws of viable drug candidates or clinically
approved drugs. However, the strategic importance of prodrugs in the pharmaceutical …

Prodrugs are an established concept to overcome barriers to a drug's usefulness. In
Germany, about 6.9% of all marketed medicines can be classified as prodrugs, an estimate …

The prodrug approach to resolving formulation, delivery, and toxicity limitations on
problematic drugs has had its proponents and detractors. Over the last 10 years or so, about …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

The study of prodrugs that are chemically modified bioreversible derivatives of active drug
compounds to alter their undesired properties has been expanded widely during the last …

Prodrugs are substances administered in an inactive form that is then metabolized in the
body in vivo into the active compound. The rationale behind administering prodrugs is to …