Micro-and nano-structured substrates have been widely used in the biomedical engineering
field. Their precise control of cell morphology makes them promising for investigating …

Micropatterning technology is a highly advantageous approach for directly assessing and
comparing the effects of different factors on stem cell functions. In this study, poly (vinyl …

Surface nanotopographies are an important way of mimicking the stem cell niche on
biomaterial surfaces. Previous studies have focused on the differentiation of stem cells into a …

Topographic cues have been recognized crucial on the modulation of cell behavior, and
subsequent important for the design of implants, cell-based biomedical devices and tissue …

Living cells receive biochemical and physical information from the surrounding
microenvironment and respond to this information. Multiscale hierarchical substrates with …

Many studies have demonstrated the potential to modulate stem cell differentiation by using
static material substrate surfaces. However, cells actually grow in a dynamically diverse …

Directing stem cells towards a desired location and function by utilizing the structural cues of
biomaterials is a promising approach for inducing effective tissue regeneration. Here, the …

Cell–cell interaction plays an important role in the control of cell functions. The precise
control of cell–cell interaction will provide a useful tool to elucidate its influence on stem cell …

There is increasing evidence that microstructures play an important role in the maintenance
of the multipotency of stem cells. However, it is not clear how micropatterns affect the …

Micropatterns of arginine–glycine–aspartic acid (RGD) on poly (ethylene glycol)(PEG)
hydrogels were fabricated. Under an appropriate size of microislands on this strong and …