Background Tuberculosis (TB) is the leading infectious cause of mortality worldwide. In the
last years, resistant strains of the etiological agent, Mycobacterium tuberculosis, have …

SETTING: Systematic screening for active pulmonary tuberculosis (PTB) is recommended for
high-risk populations, including people living with the human immunodeficiency virus …

Introduction A highly sensitive triage test that captures most symptomatic patients at
increased likelihood of having pulmonary tuberculosis (PTB) would 'rule-out'lower-risk …

BACKGROUND: Rapid means of ruling in or ruling out tuberculosis (TB) would permit more
efficient management of patients starting antiretroviral treatment (ART). OBJECTIVE: To …

Background Identification of an accurate, low-cost triage test for pulmonary TB among
people presenting to healthcare facilities is an urgent global research priority. We assessed …

OBJECTIVE: To determine the accuracy and role of rapid C-reactive protein (CRP) testing in
human immunodeficiency virus (HIV) infected individuals with presumed tuberculosis (TB) …

Background Delayed diagnosis has contributed to the high mortality of sputum smear-
negative tuberculosis (SNTB) in high HIV prevalence countries. New diagnostic strategies …

Background: There is an urgent need for more accurate screening tests for tuberculosis (TB).
We assessed the diagnostic accuracy of C-reactive protein (CRP) as a screening test for …

Background Symptom-based screening for tuberculosis is recommended for all people
living with HIV. This recommendation results in unnecessary Xpert MTB/RIF testing in many …

Background Tuberculosis, a major cause of death in people living with HIV, remains
challenging to diagnose. Diagnostic accuracy data are scarce for promising triage and …