Maintenance of endothelial cell tube integrity is dependent on an intact cytoskeleton. We
present data indicating that rapid collapse of endothelial tubular networks in vitro occurs in a …

Endothelial cells undergo branching morphogenesis to form capillary tubes. We have
utilized an in vitro Matrigel overlay assay to analyze the role of the cytoskeleton and Rho …

Capillary endothelial cells can be switched between growth and apoptosis by modulating
their shape with the use of micropatterned adhesive islands. The present study was carried …

The mechanisms that control organization of endothelial cells (ECs) into new blood vessels
are poorly understood. We hypothesized that the GTPase Rho, which regulates cytoskeletal …

Actin cytoskeletal disruption is a hallmark of ischemic injury and ATP depletion in a number
of cell types, including renal epithelial cells. We manipulated Rho GTPase signaling by …

Ischemic injury is characterized by a loss of cell polarity and a release of proximal tubule
epithelial cells resulting from cytoskeletal reorganization. This study used a reversible …

Microtubules tightly regulate various cellular activities. Our understanding of microtubules is
largely based on experiments using microtubule‐targeting agents, which, however, are …

Previous experiments using cultured endothelial monolayers indicate that Rho‐family small
GTPases are involved in modulation of endothelial monolayer permeability by regulating …

Abstract Changes in microtubule polymerization state have been shown to affect many
cellular events, including the contractile properties of smooth muscle. We have previously …

Proximal tubular epithelial cells differ from other epithelial cells in the expression of N‐
cadherin as major adherens junction protein instead of E‐cadherin. Migration of proximal …