The modulation of endothelial barrier function is thought to be a function of contractile
tension mediated by the cell cytoskeleton, which consists of actomyosin stress fibers (SF) …

Microtubules undergo continual dynamic changes in mitotic cells as the mitotic spindle forms
and is broken down and in interphase cells where they play a central role in intracellular …

Migration of epithelial cell sheets, a process involving F-actin restructuring through Rho
family GTPases, is both physiologically and pathophysiologically important. Our objective …

Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

The interest in studying the mechanical and adhesive properties of cells has increased in
recent years. The cytoskeleton is known to play a key role in cell mechanics. However, the …

Endothelial cells play a critical role in the process of angiogenesis during skin wound
healing. The migration and proliferation of endothelial cells are processes that are initiated …

The GTPase RhoA is a major regulator of the assembly of actin stress fibers and the
contractility of the actomyosin cytoskeleton. The epidermal cell differentiation inhibitor …

Leucocytes in the bloodstream respond rapidly to inflammatory signals by crossing the
blood vessel wall and entering the tissues. This process involves adhesion to, and …

Background Endothelial cells (EC) are sensitive to changes in the microenvironment,
including hypoxia and ischemia. Disruption of the microtubular network has been reported in …

Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer.
However, some kinase inhibitors can also disrupt microtubule organization by directly …