Objective: Natural killer (NK) cells are critical immune cells for acute myeloid leukemia
(AML) targeting. However, little is known about the relationship between using checkpoint …

We have previously reported that heat shock protein 70 (HSP70) vaccination induced
natural killer (NK) cell activity in patients with chronic myelogenous leukemia (CML). In this …

Background Leukaemia is an aggressive cancer of haematopoiesis. Despite increasing
treatment success, the relapse rate is still high. Natural killer (NK) cells play a key role in the …

This study aimed to characterize different natural killer (NK) cell phenotypes on bone
marrow and peripheral blood cells from acute myeloid leukemia (AML) patients and healthy …

Membrane-bound heat shock protein 70 (HSP70) was found to be tumor-specific and was
proposed as a target for immunotherapy. In the present study, we analyzed cell surface and …

This study compared the effects of the human 70-kDa stress protein (Hsp70) peptide,
TKDNNLLGRFELSG (TKD), proinflammatory cytokines, or a combination of both on the …

Background: Although there is convincing data in support of the effectiveness of
hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of …

Despite recent progress in the therapeutic approach of malignant hemopathies, their
prognoses remain frequently poor. Immunotherapy could open a new window of great …

Background: Programmed death-1 (PD-1) and T-cell immunoglobulin-and mucin-domain-
containing molecule-3 (Tim-3) are two major immune checkpoint receptors expressed on …

It is known that treatments with heat shock, some anticancer drugs, and ionizing radiation
increase the expression of heat-shock proteins (HSPs) and natural killer group 2D (NKG2D) …