T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Highlights•Metabolic reprogramming is intimately linked to T cell activation.•Different T cell
subsets have different metabolic demands.•Selectivity of targeting metabolism is achieved …

In the past several years a wealth of evidence has emerged illustrating how metabolism
supports many aspects of T cell biology, as well as how metabolic changes drive T cell …

T cell growth and function must be tightly regulated to provide protection against foreign
pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T …

T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Recent advances in the field of immunometabolism support the concept that fundamental
processes in T cell biology, such as TCR-mediated activation and T helper lineage …

T lymphocytes are a critical component of the adaptive immune system mediating protection
against infection and malignancy, but also implicated in many immune pathologies. Upon …

T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …

T cells are an important adaptive immune response arm that mediates cell-mediated
immunity. T cell metabolism plays a central role in T cell activation, proliferation …