Treating to target in chronic diseases [eg Major Depressive Disorder (MDD)] fosters
precision, consistency, and appropriateness of treatment selection and sequencing …

Depression is associated with significant functional impairment and reduced quality of life.
Disruptions occur both globally as well as in specific functional areas such as work …

Objective: This article presents the case that a more rapid, individualized approach to
treating major depressive disorder (MDD) may increase the likelihood of achieving full …

Individual patients with depression present with unique symptom clusters–before, during,
and even after treatment. The prevalence of persistent, unresolved symptoms and their …

Background With symptomatic remission and functional recovery as the overarching
therapeutic objectives of antidepressant therapy, composite endpoint measures that …

Objective: Almost two-thirds of patients with major depressive disorder do not achieve
remission with initial treatments. Thus, identifying and providing effective, feasible, and safe …

Major depressive disorder is an often chronic and recurring illness. Left untreated, major
depressive disorder may result in progressive alterations in brain morphometry and circuit …

Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Response to pharmacologic treatment is generally evaluated by traditional clinician-and …

Despite many advances in pharmacotherapy over the past half centurye, only a fraction of
patients with Major Depressive Disorder (MDD) can achieve remission after the first or …

Major depressive disorder (MDD) is an illness of great morbidity that affects many people
across the world. The current goal for treatment of MDD is to achieve remission (ie, no …