Mechanism and applications of CRISPR/Cas-9-mediated genome editing

M Asmamaw, B Zawdie - Biologics: targets and therapy, 2021 - Taylor & Francis
Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …

[HTML][HTML] Focus: Genome editing: Science and bioethics of CRISPR-Cas9 gene editing: An analysis towards separating facts and fiction

AP Cribbs, SMW Perera - The Yale journal of biology and medicine, 2017 - ncbi.nlm.nih.gov
Since its emergence in 2012, the genome editing technique known as CRISPR-Cas9 and its
scientific use have rapidly expanded globally within a very short period of time. The …

CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine

FV Jacinto, W Link, BI Ferreira - Journal of cellular and …, 2020 - Wiley Online Library
The recent development of the CRISPR/Cas9 system as an efficient and accessible
programmable genome‐editing tool has revolutionized basic science research …

CRISPR-Cas9 gene editing: Delivery aspects and therapeutic potential

EO Blenke, MJW Evers, E Mastrobattista… - Journal of Controlled …, 2016 - Elsevier
The CRISPR-Cas9 gene editing system has taken the biomedical science field by storm,
initiating rumors about future Nobel Prizes and heating up a fierce patent war, but also …

[HTML][HTML] Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

M Khoshandam, H Soltaninejad, M Mousazadeh… - Genes & …, 2024 - Elsevier
CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …

[HTML][HTML] The power and the promise of CRISPR/Cas9 genome editing for clinical application with gene therapy

N Guo, JB Liu, W Li, YS Ma, D Fu - Journal of Advanced Research, 2022 - Elsevier
Abstract Background Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
is derived from the bacterial innate immune system and engineered as a robust gene-editing …

Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications

G Bhattacharjee, N Gohil, K Khambhati, I Mani… - Journal of Controlled …, 2022 - Elsevier
A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …

[HTML][HTML] Various aspects of a gene editing system—crispr–cas9

E Janik, M Niemcewicz, M Ceremuga… - International journal of …, 2020 - mdpi.com
The discovery of clustered, regularly interspaced short palindromic repeats (CRISPR) and
their cooperation with CRISPR-associated (Cas) genes is one of the greatest advances of …

CRISPR–Cas9 in genome editing: Its function and medical applications

S Khadempar, S Familghadakchi… - Journal of cellular …, 2019 - Wiley Online Library
The targeted genome modification using RNA‐guided nucleases is associated with several
advantages such as a rapid, easy, and efficient method that not only provides the …

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

C Liu, L Zhang, H Liu, K Cheng - Journal of controlled release, 2017 - Elsevier
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …