Background Among children, sex-specific differences in disease prevalence, age of onset,
and susceptibility have been observed in health conditions including asthma, immune …

Background Preterm birth and shorter duration of pregnancy are associated with increased
morbidity in neonatal and later life. As the epigenome is known to have an important role …

DNA methylation (DNAm) is known to play a pivotal role in childhood health and
development, but a comprehensive characterization of genome-wide DNAm trajectories …

Background DNA methylation is an important epigenetic mark that can potentially link early
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …

Birthweight is associated with health outcomes across the life course, DNA methylation may
be an underlying mechanism. In this meta-analysis of epigenome-wide association studies …

Prenatal development and early childhood are critical periods for establishing the tissue-
specific epigenome, and may have a profound impact on health and disease in later life …

Background Preterm birth confers a high risk of adverse long term health outcomes for
survivors, yet the underlying molecular mechanisms are unclear. We hypothesized that …

Background Changes in DNA methylation patterns with age frequently have been observed
and implicated in the normal aging process and its associated increasing risk of disease …

Background: Association studies of epigenome-wide DNA methylation and disease can
inform biological mechanisms. DNA methylation is often measured in peripheral blood, with …

Background Multiple epigenome-wide association studies have been performed to identify
DNA methylation patterns regulated by aging or correlated with risk of death. However, the …