Advances in Chagas disease drug development: 2009–2010 : Current Opinion in Infectious
Diseases Advances in Chagas disease drug development: 2009–2010 : Current Opinion in …

The interaction between the protozoan parasite Trypanosoma cruzi and the human host
dates back 9,000 years, as demonstrated by molecular analysis of material obtained from …

Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …

Introduction Chagas disease treatment relies on the lengthy administration of benznidazole
and/or nifurtimox, which have frequent toxicity associated. The disease, caused by the …

Chagas disease is a neglected tropical disease and a global public health issue. In terms of
treatment, no progress has been made since the 1960s, when benznidazole and nifurtimox …

Chagas disease is the highest impact parasitic disease in the Americas but often goes
untreated due to the shortcomings of currently available therapeutics. Thus there is an …

Chagas disease represents a serious burden for millions of people worldwide. Transmitted
by the protozoan parasite Trypanosoma cruzi, this neglected tropical disease causes more …

Introduction: Chagas disease is a chronic infection associated with long-term morbidity.
Increased funding and advocacy for drug discovery for neglected diseases have prompted …

Cell-based screening has become the major compound interrogation strategy in Chagas
disease drug discovery. Several different cell lines have been deployed as host cells in …

Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …