Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …

Telomere maintenance mechanisms (ie, telomerase activity (TA) and the alternative
lengthening of telomere (ALT) mechanism) contribute to tumorigenesis by providing …

The replicative immortality of human cancer cells is achieved by activation of a telomere
maintenance mechanism (TMM). To achieve this, cancer cells utilise either the enzyme …

The vast majority of cancers commandeer the activity of telomerase-the remarkable enzyme
responsible for prolonging cellular lifespan by maintaining the length of telomeres at the …

Approximately 10% to 15% of human cancers lack detectable telomerase activity, and a
subset of these maintain telomere lengths by the telomerase-independent telomere …

To escape replicative senescence, cancer cells have to overcome telomere attrition during
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …

Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular
immortality. A significant fraction of tumors uses the alternative lengthening of telomeres …

Activation of a telomere maintenance mechanism (TMM) is permissive for replicative
immortality and a hallmark of human cancer. While most cancers rely on reactivation of …

To grow indefinitely, human cancer cells must counteract the progressive loss of telomeric
DNA that universally accompanies cell division. To do this, about 85 to 90% of cancers use …

Alternative Lengthening of Telomeres (ALT) activity can be deduced from the presence of
telomere length maintenance in the absence of telomerase activity. More convenient assays …