Integrated or independent actions of metformin in target tissues underlying its current use and new possible applications in the endocrine and metabolic disorder area

G Tulipano - International journal of molecular sciences, 2021 - mdpi.com
Metformin is considered the first-choice drug for type 2 diabetes treatment. Actually,
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …

Multifaceted mechanisms of action of metformin which have been unraveled one after another in the long history

H Kaneto, T Kimura, A Obata, M Shimoda… - International Journal of …, 2021 - mdpi.com
While there are various kinds of drugs for type 2 diabetes mellitus at present, in this review
article, we focus on metformin which is an insulin sensitizer and is often used as a first …

Metformin in therapeutic applications in human diseases: Its mechanism of action and clinical study

Y Du, YJ Zhu, YX Zhou, J Ding, JY Liu - Molecular Biomedicine, 2022 - Springer
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

Metformin: A review of potential mechanism and therapeutic utility beyond diabetes

S Dutta, RB Shah, S Singhal, SB Dutta… - Drug design …, 2023 - Taylor & Francis
Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

[HTML][HTML] Metformin and its benefits for various diseases

Z Lv, Y Guo - Frontiers in endocrinology, 2020 - frontiersin.org
Metformin is a widely used biguanide drug due to its safety and low cost. It has been used
for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability …

Molecular mechanisms of action of metformin: latest advances and therapeutic implications

H Zhu, Z Jia, YR Li, I Danelisen - Clinical and experimental medicine, 2023 - Springer
Metformin is among the most widely used antidiabetic drugs. Studies over the past few years
have identified multiple novel molecular targets and pathways that metformin acts on to exert …

Metformin and cancer, an ambiguanidous relationship

SJ Skuli, S Alomari, H Gaitsch, A Bakayoko, N Skuli… - Pharmaceuticals, 2022 - mdpi.com
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …

Anti-diabetic drug metformin: challenges and perspectives for cancer therapy

K Sreenivasan Snima, P Pillai… - Current cancer drug …, 2014 - ingentaconnect.com
Metformin, a biguanide, is a commonly administered drug for the management of type 2
diabetes mellitus. The drug received tremendous recognition, when retrospective studies …

Metformin: an old drug with new applications

J Zhou, S Massey, D Story, L Li - International journal of molecular …, 2018 - mdpi.com
Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …

Metformin: A Dual-Role Player in Cancer Treatment and Prevention

MA Galal, M Al-Rimawi, A Hajeer, H Dahman… - International Journal of …, 2024 - mdpi.com
Cancer continues to pose a significant global health challenge, as evidenced by the
increasing incidence rates and high mortality rates, despite the advancements made in …