Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

When is an in silico representation a digital twin? A biopharmaceutical industry approach to the digital twin concept

RMC Portela, C Varsakelis, A Richelle… - Digital Twins: Tools and …, 2021 - Springer
Digital twins (DTs) are expected to render process development and life-cycle management
much more cost-effective and time-efficient. A DT definition, a brief retrospect on their history …

Towards the development of digital twins for the bio-manufacturing industry

CL Gargalo, SC de Las Heras, MN Jones… - Digital twins: Tools and …, 2021 - Springer
The bio-manufacturing industry, along with other process industries, now has the opportunity
to be engaged in the latest industrial revolution, also known as Industry 4.0. To successfully …

Hybrid modeling—a key enabler towards realizing digital twins in biopharma?

M Sokolov, M von Stosch, H Narayanan, F Feidl… - Current Opinion in …, 2021 - Elsevier
Digital twins (DTs) represent a vividly emerging technology in the manufacturing industry
strongly motivated by the goals of industry 4.0. It strives for smart factories with completely …

A state-of-the-art survey of Digital Twin: techniques, engineering product lifecycle management and business innovation perspectives

KYH Lim, P Zheng, CH Chen - Journal of Intelligent Manufacturing, 2020 - Springer
With the rapid advancement of cyber-physical systems, Digital Twin (DT) is gaining ever-
increasing attention owing to its great capabilities to realize Industry 4.0. Enterprises from …

[HTML][HTML] Implementation of digital twins in the process industry: A systematic literature review of enablers and barriers

M Perno, L Hvam, A Haug - Computers in Industry, 2022 - Elsevier
Since the introduction of the concept of “digital twins”(DTs) in 2002, the number of practical
applications in different industrial sectors has grown rapidly. Despite the hype surrounding …

Challenges of digital twin in high value manufacturing

S Singh, E Shehab, N Higgins, K Fowler, T Tomiyama… - 2018 - sae.org
Digital Twin (DT) is a dynamic digital representation of a real-world asset, process or system.
Industry 4.0 has recognised DT as the game changer for manufacturing industries in their …

The impact of digital twins on the evolution of intelligent manufacturing and Industry 4.0

M Attaran, S Attaran, BG Celik - Advances in Computational Intelligence, 2023 - Springer
As the adoption of Industry 4.0 advances and the manufacturing process becomes
increasingly digital, the Digital Twin (DT) will prove invaluable for testing and simulating new …

Digital twins in biomanufacturing

S Zobel-Roos, A Schmidt, L Uhlenbrock, R Ditz… - Digital twins: Tools and …, 2021 - Springer
In recent years process modelling has become an established method which generates
digital twins of manufacturing plant operation with the aid of numerically solved process …

A review of digital twin technology for electromechanical products: Evolution focus throughout key lifecycle phases

Z Cui, X Yang, J Yue, X Liu, W Tao, Q Xia… - Journal of Manufacturing …, 2023 - Elsevier
The digitalization of electromechanical products creates numerous virtual resources
throughout the lifecycle, which require efficient organization and utilization. Digital twin (DT) …