Chemically defined oocyte maturation media supplemented with FGF2, LIF, and IGF-1 (FLI
medium) enabled significantly improved oocyte quality in multiple farm animals, yet the …

STUDY QUESTION Does a chemically defined maturation medium supplemented with
FGF2, LIF, and IGF1 (FLI) improve in vitro maturation (IVM) of cumulus–oocyte complexes …

Purpose We first assessed regulation of FGF2 expression in cumulus cells by FSH and
oocyte-secreted factors during in vitro maturation (IVM). Then, we tested the hypothesis that …

In porcine in vitro production (IVP) systems, the use of oocytes derived from prepubertal gilts,
whilst being commercially attractive, remains challenging due to their poor developmental …

Oocyte maturation is critical for successful fertilization and pregnancy. The mechanism
underlying the control of this complex process remain relatively unknown, and even more so …

Abstract Fibroblast growth factor 10 (FGF10) is an important regulator of the mammalian
cumulus-oocyte complex that plays a crucial role in oocyte maturation. In this study, we …

Fibroblast growth factor 2 (FGF2), a member of FGF family, binds with FGF receptors (FGFR)
to initiate biological functions in various somatic cells. However, little is known regarding the …

Abstract Fibroblast growth factor 10 (FGF10) plays critical roles in oocyte maturation and
embryonic development; however, the specific pathway by which FGF10 promotes in vitro …

BACKGROUND Successful oocyte in vitro maturation (IVM) would eliminate the need for
hormonal stimulation used in assisted reproduction techniques. Unfortunately, oocytes …

We evaluated the effect of supplementation of different concentrations of bovine follicular
fluid (FF) during in vitro maturation (IVM) on oocyte development and blastocyst quality in …