The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in
all human tissues. It is comprised of varying proteins, including collagens, elastin, and …

Wound healing is a complex, dynamic process required for maintaining homeostasis in an
organism. Along with being controlled biochemically, wound healing is also controlled …

Disappointing results with the use of exogenous recombinant growth factors in chronic
wounds have redirected the focus to the extracellular matrix (ECM). Newer research has …

Dynamic interactions between growth factors and extracellular matrix (ECM) are integral to
wound healing. These interactions take several forms that may be categorized as direct or …

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular
matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans …

Wound healing is the physiologic response to tissue trauma proceeding as a complex
pathway of biochemical reactions and cellular events, secreted growth factors, and …

A chronic wound fails to complete an orderly and timely reparative process and places
patients at increased risk for wound complications that negatively impact quality of life and …

The extracellular matrix (ECM) is the largest component of the dermal skin layer and the
synthesis of ECM is a key feature of wound healing, especially when there has been a …

The extracellular matrix (ECM) consists of a complex mixture of structural and functional
proteins and serves an important role in tissue and organ morphogenesis, maintenance of …

Significance: When a cutaneous injury occurs, the wound heals via a dynamic series of
physiological events, including coagulation, granulation tissue formation, re …