Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

BG Yipp, B Petri, D Salina, CN Jenne, BNV Scott… - Nature medicine, 2012 - nature.com
Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process
requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils …

Neutrophil extracellular traps in host defense

SS Burgener, K Schroder - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
Neutrophils are produced in the bone marrow and then patrol blood vessels from which they
can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill …

[HTML][HTML] Diverse stimuli engage different neutrophil extracellular trap pathways

EF Kenny, A Herzig, R Krüger, A Muth, S Mondal… - Elife, 2017 - elifesciences.org
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and
have pathogenic functions in diverse diseases. We examined the NETosis pathways …

NETosis: how vital is it?

BG Yipp, P Kubes - Blood, The Journal of the American Society …, 2013 - ashpublications.org
In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various …

Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease

V Poli, I Zanoni - Trends in microbiology, 2023 - cell.com
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

C Schauer, C Janko, LE Munoz, Y Zhao, D Kienhöfer… - Nature medicine, 2014 - nature.com
Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils
in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously …

An emerging role for neutrophil extracellular traps in noninfectious disease

SK Jorch, P Kubes - Nature medicine, 2017 - nature.com
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils
to help catch and kill bacteria. However, increasing evidence suggests that this process …

Neutrophil extracellular traps: how to generate and visualize them

V Brinkmann, B Laube, UA Abed, C Goosmann… - JoVE (Journal of …, 2010 - jove.com
Neutrophil granulocytes are the most abundant group of leukocytes in the peripheral blood.
As professional phagocytes, they engulf bacteria and kill them intracellularly when their …

Simplified human neutrophil extracellular traps (NETs) isolation and handling

S Najmeh, J Cools-Lartigue, B Giannias… - JoVE (Journal of …, 2015 - jove.com
Neutrophil Extracellular Traps (NETs) have been recently identified as part of the
neutrophil's antimicrobial armamentarium. Apart from their role in fighting infections, recent …

[HTML][HTML] Molecular mechanisms regulating NETosis in infection and disease

N Branzk, V Papayannopoulos - Seminars in immunopathology, 2013 - Springer
Neutrophils are the foot soldiers of the immune system. They home in to the site of infection
and kill pathogens by phagocytosis, degranulation, and the release of web-like structures …