The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Mammalian skin research represents the convergence of three complementary disciplines:
cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current …

In the past years, our view of the molecular and cellular mechanisms that ensure the self-
renewal of the skin has dramatically changed. Several populations of stem cells have been …

The skin epidermis and its appendages provide a protective barrier that guards against loss
of fluids, physical trauma, and invasion by harmful microbes. To perform these functions …

Epithelial stem cells in the skin are specified during development and are governed by
epithelial–mesenchymal interactions to differentially adopt the cell fates that enable them to …

Many adult regenerative cells divide infrequently but have high proliferative capacity. We
developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion …

The skin forms a crucial, dynamic barrier between an animal and the external world. In
mammals, three stem cell populations possess robust regenerative potential to maintain and …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

The skin epidermis and its appendages provide a protective barrier that is impermeable to
harmful microbes and also prevents dehydration. To perform their functions while being …

Tissues have a natural capacity to replace dying cells and to heal wounds. This ability
resides in resident stem cells, which self-renew, preserve, and repair their tissue during …