BACKGROUND. The molecular understanding of the progression from acute to chronic
organ injury is limited. Ischemia/reperfusion injury (IRI) triggered during kidney …

Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

BACKGROUND Longitudinal investigations of murine acute kidney injury (AKI) suggest that
injury and inflammation may persist long after the initial insult. However, the evolution of …

Background Single-cell sequencing technologies have advanced our understanding of
kidney biology and disease, but the loss of spatial information in these datasets hinders our …

Acute kidney injury (AKI) promotes an abrupt loss of kidney function that results in
substantial morbidity and mortality. Considerable effort has gone toward identification of …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

The mammalian kidney has an intrinsic ability to repair after significant injury. However, this
process is inefficient: patients are at high risk for the loss of kidney function in later life. No …

Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate and urine
production caused by a number of different diseases. It is associated with renal tissue …

Ischemia reperfusion injury (IRI) is a choreographed process leading to delayed graft
function (DGF) and reduced long-term patency of the transplanted organ. Early identification …