Adenosine receptors as drug targets
BB Fredholm - Experimental cell research, 2010 - Elsevier
There are four adenosine receptors, A1, A2A, A2B and A3, together forming a defined
subgroup of G protein coupled receptors. They are well conserved and widely expressed …
subgroup of G protein coupled receptors. They are well conserved and widely expressed …
Adenosine—a physiological or pathophysiological agent?
BB Fredholm - Journal of molecular medicine, 2014 - Springer
This minireview briefly summarizes the evidence that adenosine, acting on four G-protein
coupled receptors, can play physiological roles, but is also critically involved in pathological …
coupled receptors, can play physiological roles, but is also critically involved in pathological …
Adenosine receptors: what we know and what we are learning
ML Trincavelli, S Daniele… - Current topics in medicinal …, 2010 - ingentaconnect.com
Adenosine, beside its role in the intermediate metabolism, mediates its physiological
functions by interacting with four receptor subtypes named A1, A2A, A2B and A3. All these …
functions by interacting with four receptor subtypes named A1, A2A, A2B and A3. All these …
Differential effect of adenosine on tumor and normal cell growth: focus on the A3 adenosine receptor
G Ohana, S Bar‐Yehuda, F Barer… - Journal of cellular …, 2001 - Wiley Online Library
Adenosine is an ubiquitous nucleoside present in all body cells. It is released from
metabolically active or stressed cells and subsequently acts as a regulatory molecule …
metabolically active or stressed cells and subsequently acts as a regulatory molecule …
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2001 - ASPET
Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …
[HTML][HTML] A2A adenosine receptors in human peripheral blood cells
Adenosine mediates a wide range of physiological functions by activation of at least four cell
surface receptors named A1, A2A, A2B and A3. Each receptor subtype has been cloned and …
surface receptors named A1, A2A, A2B and A3. Each receptor subtype has been cloned and …
Introduction to adenosine receptors as therapeutic targets
KA Jacobson - Adenosine receptors in health and disease, 2009 - Springer
Adenosine acts as a cytoprotective modulator in response to stress to an organ or tissue.
Although short-lived in the circulation, it can activate four subtypes of G protein-coupled …
Although short-lived in the circulation, it can activate four subtypes of G protein-coupled …
Adenosine receptors in health and disease
The adenosine receptors A 1, A 2A, A 2B, and A 3 are important and ubiquitous mediators of
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …
cellular signaling, which play vital roles in protecting tissues and organs from damage. In …
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection
J Linden - Annual review of pharmacology and toxicology, 2001 - annualreviews.org
Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …
Adenosine and adenosine receptors: newer therapeutic perspective
S Manjunath, PM Sakhare - Indian journal of pharmacology, 2009 - journals.lww.com
Adenosine, a purine nucleoside has been described as a'retaliatory metabolite'by virtue of
its ability to function in an autocrine manner and to modify the activity of a range of cell types …
its ability to function in an autocrine manner and to modify the activity of a range of cell types …