Blinding and expectancy confounds in psychedelic randomized controlled trials

SD Muthukumaraswamy, A Forsyth… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: There is increasing interest in the potential for psychedelic drugs such as
psilocybin, LSD and ketamine to treat several mental health disorders, with a growing …

Expectancy in placebo-controlled trials of psychedelics: if so, so what?

M Butler, L Jelen, J Rucker - Psychopharmacology, 2022 - Springer
Modern psychedelic research remains in an early phase, and the eventual introduction of
psychedelics into clinical practice remains in doubt. In this piece, we discuss the role of …

Risk of bias in randomized clinical trials on psychedelic medicine: A systematic review

OR Hovmand, ED Poulsen, S Arnfred… - Journal of …, 2023 - journals.sagepub.com
Background: The classical psychedelics, psilocybin, peyote, ayahuasca/N, N-
dimethyltryptamine, and lysergic acid diethylamide are considered promising new …

Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials

JS Aday, BD Heifets, SD Pratscher, E Bradley… - …, 2022 - Springer
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Control conditions in randomized trials of psychedelics: an ACTTION systematic review

SM Nayak, MK Bradley, BA Kleykamp… - The Journal of clinical …, 2023 - psychiatrist.com
Results: In total, 126 articles were included, encompassing 86 unique studies. Of studies
with a drug control condition (80), 49 (61.2%) used an inert placebo control, 16 (20.0%) …

Should we be leery of being Leary? Concerns about psychedelic use by psychedelic researchers

B Kious, Z Schwartz, B Lewis - Journal of …, 2023 - journals.sagepub.com
Psychedelic research is proceeding rapidly, despite ongoing legal and regulatory barriers
and lingering questions about study design, such as the difficulty of ensuring adequate …

History repeating: guidelines to address common problems in psychedelic science

M van Elk, EI Fried - Therapeutic Advances in …, 2023 - journals.sagepub.com
Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …

Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?

RL Carhart-Harris, AC Wagner… - Journal of …, 2022 - journals.sagepub.com
Favourable regulatory assessments, liberal policy changes, new research centres and
substantial commercial investment signal that psychedelic therapy is making a major …

The challenges ahead for psychedelic 'medicine'

S Muthukumaraswamy, A Forsyth… - Australian & New …, 2022 - journals.sagepub.com
With the extensive public, commercial and scientific interest from what has been widely
termed the psychedelic renaissance, it is important that the scientific practices and results …

Predicting responses to psychedelics: a prospective study

ECHM Haijen, M Kaelen, L Roseman… - Frontiers in …, 2018 - frontiersin.org
Responses to psychedelics are notoriously difficult to predict, yet significant work is currently
underway to assess their therapeutic potential and the level of interest in psychedelics …