Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins,
found within the outer membrane, are involved in regulating the permeability of β-lactam …

The penetration of anionic β-lactam antibiotics through porins was evaluated as a
mechanism of drug resistance. The major proteins with porin activity were purified from the …

Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, and
Providencia alcalifaciens, which were once classified into the same genus, Proteus, were …

The outer membrane vesicles (OMVs) from bacteria are known to posses both defensive
and protective functions and thus participate in community related functions. In the present …

Outer membrane vesicles (OMVs) containing various bacterial compounds are released
from mainly gram-negative bacteria. Secreted OMVs play important roles in the ability of a …

Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by
selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were …

An integrative approach combining biophysical and microbiological methods was used to
characterize the antibiotic translocation through the outer membrane of Providencia stuartii …

Gram-negative bacteria are surrounded by a permeability barrier, the outer membrane (OM).
Hydrophilic solutes most often cross the OM through water-filled channels of porins. For …

The treatment of Stenotrophomonas maltophilia infection with β-lactam antibiotics leads to
increased release of outer membrane vesicles (OMVs), which are packed with two …

Integral membrane proteins known as porins are the major pathway by which hydrophilic
antibiotics cross the outer membrane of Gram-negative bacteria. Single point mutations in …