Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway
WY Park, JM Gray, RJ Holewinski, T Andresson, JY So… - Nature Cancer, 2023 - nature.com
Most tumor cells undergo apoptosis in circulation and at the metastatic organ sites due to
host immune surveillance and a hostile microenvironment. It remains to be elucidated …
host immune surveillance and a hostile microenvironment. It remains to be elucidated …
AGE-RAGE synergy influences programmed cell death signaling to promote cancer
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …
RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment
RAGE is a multifunctional receptor implicated in diverse processes including inflammation
and cancer. In this study, we report that RAGE expression is upregulated widely in …
and cancer. In this study, we report that RAGE expression is upregulated widely in …
[HTML][HTML] RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis
M Dahlmann, A Okhrimenko, P Marcinkowski… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Survival of colorectal cancer patients is strongly dependent on development of distant
metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis …
metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis …
RAGE regulates autophagy and apoptosis following oxidative injury
The receptor for advanced glycation end products (RAGE) plays a crucial role in several
disease processes including diabetes, inflammation, and cancer. Compared with apoptosis …
disease processes including diabetes, inflammation, and cancer. Compared with apoptosis …
RAGE up-regulation differently affects cell proliferation and migration in pancreatic cancer cells
P Swami, S Thiyagarajan, A Vidger… - International Journal of …, 2020 - mdpi.com
The receptor for advanced glycation end products (RAGE) contributes to many cellular
aspects of pancreatic cancer including cell proliferation, migration, and survival. Studies …
aspects of pancreatic cancer including cell proliferation, migration, and survival. Studies …
The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
Activation of the induced receptor for advanced glycation end products (RAGE) leads to
initiation of NF-κB and MAP kinase signaling pathways, resulting in propagation and …
initiation of NF-κB and MAP kinase signaling pathways, resulting in propagation and …
Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function
J Jules, D Maiguel, BI Hudson - PloS one, 2013 - journals.plos.org
The Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand receptor
present on most cell types. Upregulation of RAGE is seen in a number of pathological states …
present on most cell types. Upregulation of RAGE is seen in a number of pathological states …
Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis
The receptor for advanced glycation end products (RAGE) is highly expressed in various
cancers and is correlated with poorer outcome in breast and other cancers. Here we tested …
cancers and is correlated with poorer outcome in breast and other cancers. Here we tested …
RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer
RAGE (receptor for advanced glycation end-product) is thought to be associated with
metastasis and poor prognosis of various types of cancer. However, RAGE is constitutively …
metastasis and poor prognosis of various types of cancer. However, RAGE is constitutively …