Chemical-Activated Luciferase Gene Expression (CALUX): A novelin vitrobioassay for Ah receptor active compounds in sediments and pore water
This study demonstrates that the novelin vitroCALUX (chemical-activated luciferase
expression) assay is a rapid, sensitive assay for assessing the toxic potency of (mixtures of) …
expression) assay is a rapid, sensitive assay for assessing the toxic potency of (mixtures of) …
Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists
SD Seidel, V Li, GM Winter, WJ Rogers… - Toxicological …, 2000 - academic.oup.com
The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that
mediates many of the biologic and toxicologic effects of 2, 3, 7, 8-tetrachlorodibenzo-p …
mediates many of the biologic and toxicologic effects of 2, 3, 7, 8-tetrachlorodibenzo-p …
Effects of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line
M Long, P Laier, AM Vinggaard, HR Andersen… - Toxicology, 2003 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates
many of the biologic and toxicological effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin …
many of the biologic and toxicological effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin …
Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the …
JT Sanderson, JM Aarts, A Brouwer, KL Froese… - Toxicology and applied …, 1996 - Elsevier
A recombinant H4IIE rat hepatoma cell line (H4L1. 1c4, H4IIE-luc), containing a luciferase
reporter gene under control of dioxin-responsive enhancers, was examined for …
reporter gene under control of dioxin-responsive enhancers, was examined for …
In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse …
S Takeuchi, M Iida, H Yabushita, T Matsuda, H Kojima - Chemosphere, 2008 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that
regulates genes involved in xenobiotic metabolism, cellular proliferation and differentiation …
regulates genes involved in xenobiotic metabolism, cellular proliferation and differentiation …
Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits
JC Brennan, G He, T Tsutsumi, J Zhao… - … science & technology, 2015 - ACS Publications
The Ah receptor (AhR)-responsive CALUX (chemically activated luciferase expression) cell
bioassay is commonly used for rapid screening of samples for the presence of 2, 3, 7, 8 …
bioassay is commonly used for rapid screening of samples for the presence of 2, 3, 7, 8 …
Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization
A Novotna, P Pavek, Z Dvorak - Environmental science & …, 2011 - ACS Publications
We constructed stably transfected gene reporter cell line AZ-AHR, allowing measurement of
aryl hydrocarbon receptor (AhR) transcriptional activity. Human hepatoma HepG2 cells were …
aryl hydrocarbon receptor (AhR) transcriptional activity. Human hepatoma HepG2 cells were …
Third-generation Ah receptor–responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity …
G He, T Tsutsumi, B Zhao, DS Baston… - Toxicological …, 2011 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related dioxin-like
chemicals are widespread and persistent environmental contaminants that produce diverse …
chemicals are widespread and persistent environmental contaminants that produce diverse …
Species-specific recombinant cell lines as bioassay systems for the detection of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-like chemicals
PM Garrison, K Tullis, J Aarts, A Brouwer… - … and Applied Toxicology, 1996 - Elsevier
Exposure to specific polychlorinated diaromatic hydrocarbons (PCDH), such as 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD, dioxin), produces a wide variety of species-and tissue …
tetrachlorodibenzo-p-dioxin (TCDD, dioxin), produces a wide variety of species-and tissue …
Newly identified AhR-active compounds in the sediments of an industrial area using effect-directed analysis
Effect-directed analysis was used to identify previously unidentified aryl hydrocarbon
receptor (AhR) agonists in sediments collected from a highly industrialized area of Ulsan …
receptor (AhR) agonists in sediments collected from a highly industrialized area of Ulsan …