Caffeine, theophylline, theobromine, and paraxanthine administered to animals and humans
distribute in all body fluids and cross all biological membranes. They do not accumulate in …

Caffeine (TMX) disposition was studied in men after 1, 5, and 10 mg/kg in water, as mocha
coffee (1.54 mg/kg) and as a soft drink (0.22 mg/kg). TMX and its metabolites were analyzed …

The pharmacokinetics of caffeine (CA), paraxanthine (PX), theobromine (TB) and
theophylline (TP) were studied in six healthy male volunteers after oral administration of …

Some recent epidemiologic studies have reported a nonlinear dose‐response in the
relationship between coffee consumption and health risks, such that the risks increase …

Five subjects who participated in an earlier study (Lelo et al., 1986b) of the comparative
pharmacokinetics of caffeine (CA) and its primary monodemethylated metabolites …

Caffeine was conceived for a wide range of readers interested in the effects on human
health, nutrition, and physiological function of the methylxanthine beverages and foods …

The caffeine content of all tea or coffee beverages consumed by 17 healthy adults over 24
hours was measured. Plasma caffeine, theophylline, theobromine, and paraxanthine …

While there are several comprehensive reviews on the toxic effects of theophylline, caffeine
and theobromine in animals, data on the toxicity of these methylxanthines in humans have …

This review provides a brief overview of known information on the human toxicity of
theobromine and paraxanthine. Theobromine has some pharmacological effects, although …

1. Caffeine metabolism was studied in human liver microsomes from foetuses (n= 10),
neonates (n= 10), infants (n= 9) and adults (n= 5). Caffeine and its metabolites, 1‐3‐7 …