Importance Schizophrenia is associated with major cognitive deficits and has been
conceptualized as both a neurodevelopmental and a neurodegenerative disorder. However …

Importance It remains uncertain whether people with psychotic disorders experience
progressive cognitive decline or normal cognitive aging after first hospitalization. This …

Methods| We recruited 3 groups of patients:(1) individuals at clinical high-risk (CHR) for
psychosis,(2) individuals experiencing their first episode of a nonaffective psychosis (FEP; …

Schizophrenia is currently classified as a psychotic disorder. This article posits that this
emphasis on psychosis is a conceptual fallacy that has greatly contributed to the lack of …

Importance Neurocognition is a central characteristic of schizophrenia and other psychotic
disorders. Identifying the pattern and severity of neurocognitive functioning during the “near …

Importance Most patients with psychotic disorders experience severe cognitive impairment,
but the onset and course of this impairment remain unclear. Moreover, the course of …

Neurocognitive dysfunction is well established in psychosis, but recent work suggests that
processing speed deficits might represent a particularly important cognitive deficit. A number …

Importance Cognitive deficits are a key feature of risk for psychosis. Longitudinal changes in
cognitive architecture may be associated with the social and occupational functioning in …

Cognitive impairment is a well-recognized key feature of schizophrenia. Here we review the
evidence on (1) the onset and sensitive periods of change in cognitive impairment before …

Importance Although schizophrenia is characterized by impairments in intelligence and the
loss of brain volume, the relationship between changes in IQ and brain measures is not …