Liver fibrosis is an intrinsic repair process of chronic injury with excessive deposition of
extracellular matrix. As an early stage of various liver diseases, liver fibrosis is a reversible …

Inflammation contributes to the pathogenesis of liver disease, and inflammasome activation
has been identified as a major contributor to the amplification of liver inflammation …

The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome plays an important role
in liver fibrosis (LF) development. However, the mechanisms involved in NLRP3‐induced …

Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …

NLRP3 inflammasome-dependent pyroptosis has been implicated in liver fibrosis
progression. However, the definite intrahepatic cell types that undergo pyroptosis and the …

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic
liver disease worldwide. The NLRP3 inflammasome, a platform for caspase-1 activation and …

The pathogenesis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) remains
unclear and the effective treatments have not been explored yet. The activation of hepatic …

Background The NLRP3 inflammasome activation plays an important role in the
development of NASH and fibrogenesis. However, the mechanisms involved in NLRP3 …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Abstract Aims: Angiotensin II (Ang II) aggravates hepatic fibrosis by inducing NADPH
oxidase (NOX)-dependent oxidative stress. Angiotensin-(1–7)[Ang-(1–7)], which counter …