Research in the last few years has revealed a sophisticated interaction network between
multiple bone marrow cells that regulate different hematopoietic stem cell (HSC) properties …

Similar to their healthy counterpart, malignant hematopoietic stem cells in myeloid
malignancies, such as myeloproliferative neoplasms, myelodysplastic syndromes, and acute …

Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the
bone marrow (BM) microenvironment or niche. These interactions provide instructive cues …

Research in the last decade has shown that hematopoietic stem cells (HSCs) interact with
and are modulated by a complex multicellular microenvironment in the bone marrow, which …

As part of the dynamic interactions between leukemic cells and cells of the bone marrow
microenvironment, specific niches provide a sanctuary where subpopulations of leukemic …

The field of hematopoietic oncology has traditionally focused on the study of hematopoietic
cell autonomous genetic events in an effort to understand malignant transformation and …

Normal hematopoiesis is maintained by dynamic interactions between hematopoietic cells
and the bone marrow microenvironment. In hematological malignancies, there are …

In hematological malignancies, there are dynamic interactions between leukemic cells and
cells of the bone marrow microenvironment. Specific niches within the bone marrow …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

The genetic events that contribute to the pathogenesis of acute myeloid leukemia are among
the best characterized of all human malignancies. However, with notable exceptions such as …