Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

S Coutermarsh-Ott, K Eden… - Journal of General …, 2016 - microbiologyresearch.org
A complex interaction exists between elements of the host innate immune system and viral
pathogens. It is essential that the host mount a robust immune response during viral …

Central roles of NLRs and inflammasomes in viral infection

TD Kanneganti - Nature Reviews Immunology, 2010 - nature.com
The immune response to viral infections is determined by a complex interplay between the
pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral …

Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex

AM Nour, M Reichelt, CC Ku, MY Ho… - Journal of Biological …, 2011 - ASBMB
Innate cellular immunity is the immediate host response against pathogens, and activation of
innate immunity also modulates the induction of adaptive immunity. The nucleotide-binding …

NOD1, NOD2, and NLRC5 receptors in antiviral and antimycobacterial immunity

M Godkowicz, M Druszczyńska - Vaccines, 2022 - mdpi.com
The innate immune system recognizes pathogen-associated molecular motifs through
pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages …

Inflammasomes and its importance in viral infections

G Shrivastava, M León-Juárez, J García-Cordero… - Immunologic …, 2016 - Springer
A complex interplay between pathogen and host determines the immune response during
viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral …

Advances in Nod-like receptors (NLR) biology

F Barbé, T Douglas, M Saleh - Cytokine & growth factor reviews, 2014 - Elsevier
The innate immune system is composed of a wide repertoire of conserved pattern
recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in …

The expanding role of NLR s in antiviral immunity

C Lupfer, TD Kanneganti - Immunological reviews, 2013 - Wiley Online Library
Nucleotide oligomerization and binding domain (NOD)‐like receptors (NLR s) are a major
constituent of the cytosolic innate immune‐sensing machinery and participate in a wide …

Function of Nod‐like receptors in microbial recognition and host defense

L Franchi, N Warner, K Viani… - Immunological reviews, 2009 - Wiley Online Library
Nucleotide oligomerization domain (NOD)‐like receptors (NLRs) are a specialized group of
intracellular proteins that play a critical role in the regulation of the host innate immune …

NLRs, inflammasomes, and viral infection

SR Jacobs, B Damania - Journal of leukocyte biology, 2012 - academic.oup.com
Review on the interplay between NLR proteins, and RNA and DNA viruses. NLR proteins
are innate immune sensors that respond to microbial infection. Upon pathogen infection …

Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses

MS Abdul-Cader, A Amarasinghe… - Archives of virology, 2016 - Springer
Abstract Toll-like receptors (TLRs), well-characterized pattern-recognizing receptors of the
innate arm of the immune system, are vital in detecting pathogen-associated molecular …