Resistance to chemo-and radiotherapy is a common event among cancer patients and a
reason why new cancer therapies and therapeutic strategies need to be in continuous …

Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

The DNA damage response (DDR), consisting of an orchestrated network of proteins
effecting repair and signalling to cell cycle arrest, to allow time to repair, is essential for cell …

DNA damage repair (DDR) pathways are essential to ensure the accurate transmission of
genetic material. However, different endogenous and exogenous factors challenge genomic …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

DNA damage-inducing therapies are of tremendous value for cancer treatment and function
by the direct or indirect formation of DNA lesions and subsequent inhibition of cellular …

The DNA damage response (DDR) pathway coordinates the identification, signaling, and
repair of DNA damage caused by endogenous or exogenous factors and regulates cell …

The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell
cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of …

DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …

The DNA damage response (DDR) is a series of pathways and processes required to repair
lesions to DNA. These pathways range from repairing strand breaks to the double helix …