The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens
from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet …

The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate
host defense. Mucus consists of high molecular weight glycoproteins called mucins that are …

A number of mechanisms ensure that the intestine is protected from pathogens and also
against our own intestinal microbiota. The outermost of these is the secreted mucus, which …

The gastrointestinal epithelium is covered by a protective mucus gel composed
predominantly of mucin glyco-proteins that are synthesized and secreted by goblet cells …

Goblet cells (GCs) are the predominant secretory epithelial cells lining the luminal surface of
the mammalian gastrointestinal (GI) tract. Best known for their apical release of mucin 2 …

Goblet cells reside throughout the gastrointestinal (GI) tract and are responsible for the
production and preservation of a protective mucus blanket by synthesizing and secreting …

Goblet cells and their main secretory product, mucus, have long been poorly appreciated;
however, recent discoveries have changed this and placed these cells at the center stage of …

Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …

The mucus layer coating the gastrointestinal tract is the front line of innate host defense,
largely because of the secretory products of intestinal goblet cells. Goblet cells synthesize …