Scoliosis is a three-dimensional structural deformity of the spine; more than 80% of scoliosis
has no specific pathogenesis but is understood to be closely related to genetic, hormonal …

Congenital scoliosis (CS) is a congenital disease caused by malformations of vertebrae.
Recent studies demonstrated that DNA modification could contribute to the pathogenesis of …

Background: Adolescent idiopathic scoliosis (AIS) is a complex disease affecting a large
number of teenagers, especially in female. This study reveals novel epigenetic perturbation …

Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …

Background Congenital scoliosis (CS) is a congenital deformity of the spine resulting from
abnormal and asymmetrical development of vertebral bodies during pregnancy. However …

Etiology of adolescent idiopathic scoliosis (AIS), a complicated three-dimensional spinal
deformity with early-onset, receives continuous attention but remains unclear. To gain an …

Background There is considerable discordance in the curve progression of adolescent
idiopathic scoliosis (AIS) patients between monozygotic (MZ) twins, indicating that …

Idiopathic scoliosis (AIS) is the most common pediatric spinal deformity, affecting∼ 3% of
children worldwide. AIS significantly impacts national health in the US alone, creating …

Purpose Idiopathic scoliosis is a complex developmental syndrome defined by an abnormal
structural curvature of the spine. High treatment costs, chronic pain/discomfort, and the need …

Background The etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal
DNA methylation affects the growth and development of spinal development. In this study …