Astrocytes generate ATP through glycolysis and mitochondrion respiration, using glucose,
lactate, fatty acids, amino acids, and ketone bodies as metabolic fuels. Astrocytic …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

Astrocytic metabolism has taken center stage. Interposed between the neuron and the
vasculature, astrocytes exert control over the fluxes of energy and building blocks required …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

As part of the blood-brain-barrier, astrocytes are ideally positioned between cerebral
vasculature and neuronal synapses to mediate nutrient uptake from the systemic circulation …

Energy metabolism is essential for brain function. In recent years, lactate shuttling between
astrocytes and neurons has become a fundamental concept of neuroenergetics. However, it …

Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes,
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …

Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …