Introduction: Utilizing the prodrug approach as a method to overcome various
pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating …

Introduction: The molecular revolution greatly impacted the field of drug design and delivery
in general, and the utilization of the prodrug approach in particular. The increasing …

Prodrugs are bioreversible, inactive drug derivatives, which have the ability to convert into a
parent drug in the body. In the past, prodrugs were used as a last option; however …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

Generally, prodrugs are designed to improve aqueous solubility, to enhance permeability
through lipophilicity modification, to achieve site specific delivery and to increase GI …

The study of prodrugs that are chemically modified bioreversible derivatives of active drug
compounds to alter their undesired properties has been expanded widely during the last …

A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

Prodrugs as pharmacologically inactive chemical derivatives that could be used to alter the
physiochemical properties of drug in a temporary manner or to increase their usefulness and …

Prodrugs offer a versatile strategy to overcome flaws of viable drug candidates or clinically
approved drugs. However, the strategic importance of prodrugs in the pharmaceutical …

The prodrug concept has been used to improve undesirable properties of drugs since the
late 19th century, although it was only at the end of the 1950s that the actual term prodrug …