[HTML][HTML] Emerging role of hepatic ketogenesis in fatty liver disease

RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature

M Watanabe, R Tozzi, R Risi, D Tuccinardi… - Obesity …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease,
characterized by hepatic fat accumulation and possible development of inflammation …

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

DG Cotter, B Ercal, X Huang, JM Leid… - The Journal of …, 2014 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion
individuals worldwide. However, the drivers of progressive steatohepatitis remain …

[PDF][PDF] Key molecular pathways in the progression of non-alcoholic steatohepatitis.

J Tong, JJ Guo - European Review for Medical & …, 2019 - europeanreview.org
Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver
disease worldwide and also become an emerging risk factor for liver-related complications …

[HTML][HTML] Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

SH Koo - Clinical and molecular hepatology, 2013 - ncbi.nlm.nih.gov
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty
acids, and cholesterol. Increased incidence of obesity in the modern society promotes …

[HTML][HTML] Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver

JA Fletcher, S Deja, S Satapati, X Fu, SC Burgess… - JCI insight, 2019 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent, and potentially morbid,
disease that affects one-third of the US population. Normal liver safely accommodates lipid …

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

PK Luukkonen, S Dufour, K Lyu… - Proceedings of the …, 2020 - National Acad Sciences
Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic
fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite …

[HTML][HTML] Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD

MS Muyyarikkandy, M McLeod, M Maguire… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Mitochondrial adaptation during non-alcoholic fatty liver disease (NAFLD) include
remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are …

[HTML][HTML] Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

DA d'Avignon, P Puchalska, B Ercal, YJ Chang… - JCI insight, 2018 - ncbi.nlm.nih.gov
While several molecular targets are under consideration, mechanistic underpinnings of the
transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic …

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

F Marra, A Gastaldelli, GS Baroni, G Tell… - Trends in molecular …, 2008 - cell.com
Non-alcoholic steatohepatitis (NASH), a cause of cirrhosis and hepatocellular carcinoma, is
characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and …