Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless
advances in science has led to a decrease in the number of death cases caused by cancer …

Malignant tumors, known as cancer, seriously threaten human life and health. Cancer has
the characteristics of abnormal cell differentiation, proliferation, invasion and metastasis. As …

The Notch signaling pathway has a key role in cellular development and is involved in
initiation and progression of cancer by fundamentally influencing cellular processes such as …

Notch pathway is a signaling cascade with important impacts on cell proliferation,
differentiation, developmental processes and tissue homeostasis. This pathway also …

Despite their simple structure, the Notch family of receptors regulates a wide-spectrum of key
cellular processes including development, tissue patterning, cell-fate determination …

Notch signaling pathways are known to regulate many cellular processes, including cell
proliferation, apoptosis, migration, invasion, and angiogenesis, and is one of the most …

Background Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking
the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is …

MicroRNAs (miRNAs) have been implicated in the development of some if not all cancer
types and have been identified as attractive targets for prognosis, diagnosis, and therapy of …

Aim: The effects of small interfering RNA (siRNA)-mediated knockdown of NOTCH1 and
NOTCH2 on cell proliferation and downstream signaling pathways in leukemia cells were …

Cancer is a global health concern, and the prognosis of patients with cancer is associated
with metastasis. Multistep processes are involved in cancer metastasis. Accumulating …