A Synthetic Overview of New Molecules with 5-HT1A Binding Affinities Page 1 77 A Synthetic
Overview of New Molecules with 5-HT1A Binding Affinities Hernán Pessoa-Mahana*1; Ramiro …

A library consisting of 60 arylpiperazines modified with N-acylated amino acids was
prepared on BAL linker SynPhase™ Lanterns and evaluated in vitro for 5-HT1A receptor …

This report describes the effect of replacing the central basic amine present in many known
5-HT2A ligands with an aromatic residue. We targeted the isomeric phenethylpyridines 2 …

Simple syntheses of four new and potent analogues of the 5-HT1A receptor ligand, WAY-
100635 are described, namely the 6-(pyridinyl)-bromo-, the 6-(pyridinyl)-fluoro-, the …

First tricyclic oximino derivatives as 5-HT3 ligands - ScienceDirect Skip to main contentSkip to
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HT 1A R agonist or partial agonists are established drug candidates for psychiatric and
neurological disorders. We have reported the synthesis and evaluation of a series of high …

Based on our earlier studies of structure activity relationships on 4-substituted piperazine
derivatives, in this work we synthesized a novel set of long-chain arylpiperazines with the …

A series of 5-HT6 ligands derived from (R)-1-(amino) methyl-6-(phenyl) sulfonyltetralin was
prepared that yielded several non-basic analogs having sub-nanomolar affinity. Ligand …

A 5‐HT3 receptor agonist based on a benzamide scaffold was identified in a screening of a
small commercial compound library, and an elaborate SAR study originating from this hit …

A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl
linker (2–15) was synthesized and evaluated on their affinity towards serotonin 5-HT 7 …