AIM: To investigate the relationship between late SV40 factor (LSF) and Notch signaling in
the development and progress of hepatocellular carcinoma (HCC). METHODS: Liver cancer …

Abstract Aberrant Notch signaling and Ras pathway had been highlighted a potential role for
in human cancers. Yet, relatively little was known about the roles of wild type Notch …

Hepatocellular carcinoma (HCC) is a highly aggressive cancer with no currently available
effective treatment. Understanding of the molecular mechanism of HCC development and …

The transcription factor late SV40 factor (LSF) is overexpressed in human hepatocellular
carcinoma (HCC) fostering a highly aggressive and metastatic phenotype. Angiogenesis is …

The tumor suppressor p53 is a key prognostic factor in hepatocellular carcinoma (HCC), yet
only 35% of grade III tumors exhibit mutation of p53. Several other pathways have been …

BACKGROUND & AIMS: Understanding the molecular pathogenesis of hepatocellular
carcinoma (HCC) would facilitate development of targeted and effective therapies for this …

Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor
prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in …

Background: By mediating local cell-cell interactions, the Notch signaling pathway seems to
control a variety of processes from cell fate decisions during development, to stem cell …

Abstract Late SV40 factor 3 (LSF), a transcription factor, contributes to human hepatocellular
carcinoma (HCC). However, decreased expression level of LSF in skin melanoma …

Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic
cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies …