[HTML][HTML] Morphological and morphometric changes and epithelial apoptosis are induced in rat epididymis by long-term letrozole administration

A Pilutin, K Misiakiewicz-Has, S Rzeszotek… - European Journal of …, 2021 - ncbi.nlm.nih.gov
The epididymis is an organ that plays a key role in sperm maturation. The aim of this study
was to examine the association between the chronic treatment of mature male rats with …

Testis morphology in rats chronically treated with letrozole, an aromatase inhibitor

A Kondarewicz, A Kolasa, B Zawiślak… - Folia Histochemica …, 2011 - journals.viamedica.pl
The aim of this study was to investigate the influence of the long-term treatment of rats with
letrozole on the testis morphology. The pharmacologically induced estrogen deficiency …

The immunoexpression of androgen receptor, estrogen receptors alpha and beta, vanilloid type 1 receptor and cytochrome p450 aromatase in rats testis chronically …

A Pilutin, K Misiakiewicz-Has, A Kolasa… - Folia Histochemica …, 2014 - journals.viamedica.pl
The function of testis is under hormonal control and any disturbance of hormonal
homeostasis can lead to morphological and physiological changes. Therefore the aim of the …

Histological study on the effect of aroclor 1254 on the epididymis of adult rats and the role of L-NAME administration

NF Mazen, RA Zidan - Ultrastructural Pathology, 2017 - Taylor & Francis
Introduction: Aroclor 1254, a commercial polychlorinated biphenyls (PCBs) mixture, was
found to elicit various adverse effects on human health. Objectives: This study aimed to …

Evaluation of the possible protective role of quercetin on letrozole-induced testicular injury in male albino rats

ME Selim, NA Aleisa, MH Daghestani - Ultrastructural Pathology, 2013 - Taylor & Francis
Background: The purpose of this study was to appraise the possible adverse effects of
quercetin against the aromatase inhibitor letrozole-induced developmental toxicity potential …

[HTML][HTML] Effect of aromatase inhibitor letrozole on the proliferation of spermatogonia by regulating the MAPK pathway

S Wang, S Wang, H Li, X Li, M Xie… - Experimental and …, 2018 - spandidos-publications.com
The molecular mechanism of the aromatase inhibitor letrozole was investigated. It promotes
the proliferation of spermatogonia by regulating the mitogen‑activated protein kinase …

Effect of testosterone on epithelial cell proliferation in the regressed rat epididymis

M Hamzeh, B Robaire - Journal of andrology, 2009 - Wiley Online Library
It is well established that testosterone plays a crucial role in maintaining the integrity of
epididymal structure and function. However, the role of testosterone in restoring the cellular …

Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study

R Verma, A Krishna - General and Comparative Endocrinology, 2017 - Elsevier
The aim of present study was to evaluate the significance of estradiol (E2) in testicular
activities and to find out the mechanism by which E2 regulates spermatogenesis in mice. To …

[HTML][HTML] Stereological study of the effects of letrozole and estradiol valerate treatment on the ovary of rats

A Noorafshan, M Ahmadi, SF Mesbah… - Clinical and …, 2013 - ncbi.nlm.nih.gov
Objective Letrozole and estradiol valerate are used to treat some hormonally-responsive
symptoms and also in modeling of the polycystic ovary syndrome. However, the …

Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models

ER Kadir, AD Yakub, LS Ojulari, AO Hussein, IA Lawal… - Tissue and Cell, 2024 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common gynaecological, endocrine disorder
that occurs during reproductive age and is a significant cause of anovulatory infertility …