Heart rate is accelerated to match physiological demands through the action of
noradrenaline on the cardiac pacemaker. Noradrenaline is released from sympathetic …

The architectural specializations and targeted delivery pathways of cardiomyocytes ensure
that L-type Ca 2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …

Influx of Ca2+ through L-type Ca2+ channels (LTCCs) contributes to numerous cellular
processes in cardiomyocytes including excitation–contraction (EC) coupling, membrane …

Background: Beta-2 adrenergic receptors (β2ARs) but not beta-2 adrenergic receptors
(β1ARs) form a functional complex with L-type Ca2+ channels (LTCCs) on the …

Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and
contribute to mechanical regulation of cellular function. While the role of caveolae in …

Background—Distinct subpopulations of L-type calcium channels (LTCCs) with different
functional properties exist in cardiomyocytes. Disruption of cellular structure may affect …

L-type Ca2+ channels play a critical role in regulating Ca2+-dependent signaling in cardiac
myocytes, including excitation-contraction coupling; however, the subcellular localization of …

Aims L-type Ca2+ channels (LTCCs) in adult cardiomyocytes are localized to t-tubules
where they initiate excitation-contraction coupling. Our recent work has shown that a …

In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs)
following membrane depolarization regulates crucial Ca2+-dependent processes including …

Inotropy and lusitropy in the ventricular myocyte can be efficiently induced by activation of β1-
, but not β2-, adrenoceptors (ARs). Compartmentation of β2-AR-derived cAMP-dependent …