Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Antibiotic treatments increasingly fail due to rapid dissemination of drug resistance.
Comparative genomics of clinical isolates highlights the role of de novo adaptive mutations …

Antibiotics are the pivotal pillar of contemporary healthcare and have contributed towards its
advancement over the decades. Antibiotic resistance emerged as a critical warning to public …

Despite our continuous improvement in understanding antibiotic resistance, the interplay
between natural selection of resistance mutations and the environment remains unclear. To …

BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

Antibiotic combinations are considered a relevant strategy to tackle the global antibiotic
resistance crisis since they are believed to increase treatment efficacy and reduce …

Antibiotic resistance carries a fitness cost that could potentially limit the spread of resistance
in bacterial pathogens. In spite of this cost, a large number of experimental evolution studies …

The evolution of antibiotic resistance can now be rapidly tracked with high-throughput
technologies for bacterial genotyping and phenotyping. Combined with new approaches to …

Revealing the genetic changes responsible for antibiotic resistance can be critical for
developing novel antibiotic therapies. However, systematic studies correlating genotype to …

History, chance, and selection are the fundamental factors that drive and constrain evolution.
We designed evolution experiments to disentangle and quantify effects of these forces on …