Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

DNA methylation is a dynamic epigenetic modification with a prominent role in determining
mammalian cell development, lineage identity, and transcriptional regulation. Primarily …

To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …

Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …

DNA methylation is now widely recognized as being critical to maintain the function of
immune cells. Recent studies suggest that aberrant DNA methylation levels not only can …

Advances in genomic technology have enabled a greater understanding of the genetics of
common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory …

DNA methylation is the most important epigenetic modification involved in the regulation of
transcription, imprinting, establishment of X-inactivation, and the formation of a chromatin …

B lymphocytes play key roles in adaptive and innate immunity. In autoimmune diseases,
their participation in disease instigation and/or progression has been demonstrated in both …

Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding
RNAs are known regulators of gene expression and genomic stability in cell growth …

DNA methylation at cytosines followed by guanines, CpGs, forms one of the multiple layers
of epigenetic mechanisms controlling and modulating gene expression through chromatin …