CENP-A is a centromere-specific histone H3 variant that is required to ensure kinetochore
assembly for proper chromosome segregation and its function is highly conserved among …

In many eukaryotes, the centromere is epigenetically specified and not strictly defined by
sequence. In contrast, budding yeast has a specific 125 bp sequence required for …

Kinetochores are the specialized protein structures that form on centromeric DNA and direct
chromosome segregation. It is critical that all chromosomes assemble a single kinetochore …

Centromere integrity underlies an essential framework for precise chromosome segregation
and epigenetic inheritance. Although centromeric DNA sequences vary among different …

CENP-A is a histone H3-like protein specific to centromeres that is essential for kinetochore
formation and accurate chromosome segregation in eukaryotes. Recent studies (Dunleavy …

Aneuploidy, one of the most common hallmarks of cancer, results from defects in
chromosome segregation during cell division. Once cells replicate their genome, sister …

The centromere is a specific chromosomal locus that organizes the assembly of the
kinetochore. It plays a fundamental role in accurate chromosome segregation. In most …

Centromeres are the sites of assembly of the kinetochore, which connect the chromatids to
the microtubules for sister chromatid segregation during cell division. Centromeres are …

Centromeres of eukaryotic chromosomes mark the site for kinetochore formation and
microtubule attachment and are essential for accurate chromosome segregation. Although …

The enrichment of histone H3 variant CENP-A is the epigenetic mark of centromere and
initiates the assembly of the kinetochore at centromere. The kinetochore is a multi-subunit …