Unravelling the mystery of capsaicin: a tool to understand and treat pain

J O'Neill, C Brock, AE Olesen, T Andresen… - Pharmacological …, 2012 - ASPET
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

Mechanisms and clinical uses of capsaicin

SK Sharma, AS Vij, M Sharma - European journal of pharmacology, 2013 - Elsevier
Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses

V Fattori, MSN Hohmann, AC Rossaneis… - Molecules, 2016 - mdpi.com
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases

S Basith, M Cui, S Hong, S Choi - Molecules, 2016 - mdpi.com
Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum
fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been …

[HTML][HTML] Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain

V Arora, JN Campbell, MK Chung - Pharmacology & therapeutics, 2021 - Elsevier
Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Topical capsaicin. The fire of a 'hot'medicine is reignited

ADP Papoiu, G Yosipovitch - Expert opinion on pharmacotherapy, 2010 - Taylor & Francis
Importance of the field: Capsaicin and its receptor, TRPV1, occupy a central place in current
neurophysiological studies regarding pain transmission and have opened new avenues for …

Research progress of capsaicin responses to various pharmacological challenges

P Patowary, MP Pathak, K Zaman, PS Raju… - Biomedicine & …, 2017 - Elsevier
Capsaicin, a well known vanilloid, has shown evidence of an ample variety of biological
effects which make it the target of extensive research ever since its identification. In spite of …

Capsaicin, nociception and pain

B Frias, A Merighi - Molecules, 2016 - mdpi.com
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Capsaicin: A review of its pharmacology and clinical applications

M Hayman, PCA Kam - Current Anaesthesia & Critical Care, 2008 - Elsevier
Capsaicin is a naturally occurring alkaloid derived from chillies that is responsible for its hot
pungent taste. It is an odourless fat soluble compound that is rapidly absorbed through the …

Use of capsaicin to treat pain: mechanistic and therapeutic considerations

MK Chung, JN Campbell - Pharmaceuticals, 2016 - mdpi.com
Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …