Regulation of PI3K/Akt/GSK‐3 pathway by cannabinoids in the brain

A Ozaita, E Puighermanal… - Journal of …, 2007 - Wiley Online Library
Abstract Delta9‐tetrahydrocannabinol (THC), the main psychoactive component in
Cannabis sativa preparations, exerts its central effects mainly through the G‐protein coupled …

Tetrahydrocannabinol‐induced neurotoxicity depends on CB1 receptor‐mediated c‐Jun N‐terminal kinase activation in cultured cortical neurons

EJ Downer, MP Fogarty… - British journal of …, 2003 - Wiley Online Library
Δ9‐Tetrahydrocannabinol (THC), the main psychoactive ingredient of marijuana, induces
apoptosis in cultured cortical neurons. THC exerts its apoptotic effects in cortical neurons by …

Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling

F Molina-Holgado, E Pinteaux, L Heenan… - Molecular and Cellular …, 2005 - Elsevier
Cannabinoids (CBs) are neuroprotective in vivo and in vitro, but the mechanisms of their
actions are unknown. The aim of this study was to elucidate the signaling pathways that …

The multiplicity of action of cannabinoids: implications for treating neurodegeneration

A Gowran, J Noonan… - CNS neuroscience & …, 2011 - Wiley Online Library
The cannabinoid (CB) system is widespread in the central nervous system and is crucial for
controlling a range of neurophysiological processes such as pain, appetite, and cognition …

Δ9‐tetrahydrocannabinol‐induced MAPK/ERK and Elk‐1 activation in vivo depends on dopaminergic transmission

E Valjent, C Pagès, M Rogard… - European Journal of …, 2001 - Wiley Online Library
It is now well established that central effects of Δ9‐tetrahydrocannabinol (THC), the main
psychoactive component of marijuana, are mediated by CB1 cannabinoid receptors …

Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity

SH Kim, SJ Won, XO Mao, K Jin, DA Greenberg - Molecular pharmacology, 2006 - ASPET
Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms
involved by studying N-methyl-d-aspartate (NMDA) toxicity in cultured murine …

Cannabinoids activate p38 mitogen‐activated protein kinases through CB1 receptors in hippocampus

P Derkinderen, C Ledent, M Parmentier… - Journal of …, 2001 - Wiley Online Library
Cannabinoid receptors (CB1‐R) are the target of a novel class of neuromodulators, the
endocannabinoids. Yet, their signalling mechanisms in adult brain are poorly understood …

Mechanism of extracellular signal-regulated kinase activation by the CB1 cannabinoid receptor

I Galve-Roperh, D Rueda, TG del Pulgar… - Molecular …, 2002 - ASPET
Cannabinoids, the active components of marijuana and their endogenous counterparts,
exert many of their actions in brain through the seven-transmembrane receptor CB1. This …

Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons

A Straiker, M Dvorakova, A Zimmowitch… - Molecular pharmacology, 2018 - ASPET
Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two main cannabinoid
constituents of marijuana and hashish. The pharmacology of Δ9-THC has been extensively …

A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT1A …

C Echeverry, G Prunell, C Narbondo… - Neurotoxicity …, 2021 - Springer
Previous preclinical studies have demonstrated that cannabidiol (CBD) and cannabigerol
(CBG), two non-psychotomimetic phytocannabinoids from Cannabis sativa, induce …