[HTML][HTML] Nanoparticle-mediated pulmonary drug delivery: State of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections

Z Huang, SN Kłodzińska, F Wan… - Drug delivery and …, 2021 - Springer
Recalcitrant respiratory tract infections caused by bacteria have emerged as one of the
greatest health challenges worldwide. Aerosolized antimicrobial therapy is becoming …

Nanoparticles for drug delivery to the lungs

JC Sung, BL Pulliam, DA Edwards - Trends in biotechnology, 2007 - cell.com
The lungs are an attractive route for non-invasive drug delivery with advantages for both
systemic and local applications. Incorporating therapeutics with polymeric nanoparticles …

Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy

Z Jin, Q Gao, K Wu, J Ouyang, W Guo… - Advanced Drug Delivery …, 2023 - Elsevier
The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

Inhaled nano-and microparticles for drug delivery

IM El-Sherbiny, NM El-Baz, MH Yacoub - Global Cardiology Science …, 2015 - qscience.com
The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local
drug delivery, due to the lung's favourable properties of a large surface area and high …

Medical nanoparticles for next generation drug delivery to the lungs

SH van Rijt, T Bein, S Meiners - 2014 - Eur Respiratory Soc
Respiratory diseases are an increasing burden for the ageing population. Although our
understanding of these diseases has improved significantly over the past decades …

Pulmonary drug delivery: a review on nanocarriers for antibacterial chemotherapy

M Moreno-Sastre, M Pastor, CJ Salomon… - Journal of …, 2015 - academic.oup.com
As the WHO stated, lower respiratory infections are the third leading cause of death. In
addition, it is remarkable that antimicrobial resistance represents a huge threat. Thus, new …

Nanoparticles: characteristics, mechanisms of action, and toxicity in pulmonary drug delivery—a review

S Gill, R Löbenberg, T Ku, S Azarmi… - Journal of …, 2007 - ingentaconnect.com
The pulmonary route has recently gained momentum as a suitable avenue for drug delivery.
The large alveolar surface area of approximately 75 m2 coupled with the thin epithelial …

Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

E Kole, K Jadhav, N Shirsath, P Dudhe… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

Polymeric nanoparticles in development for treatment of pulmonary infectious diseases

YH Lim, KM Tiemann, DA Hunstad… - Wiley …, 2016 - Wiley Online Library
Serious lung infections, such as pneumonia, tuberculosis, and chronic obstructive cystic
fibrosis‐related bacterial diseases, are increasingly difficult to treat and can be life …

Nanoparticle formulations in pulmonary drug delivery

MM Bailey, CJ Berkland - Medicinal research reviews, 2009 - Wiley Online Library
The advent of nanotechnology has reignited interest in the lungs as a major route of drug
delivery for both systemic and local treatments. The large surface area of the lungs and the …