The retrosplenial cortex (RSC) is a vital area for storing remote memory and has recently
been found to undergo broad changes after peripheral nerve injury. However, little is known …

Background Peripheral nerve injury leads to changes in gene expression in primary sensory
neurons of the injured dorsal root ganglia. These changes are believed to be involved in …

Chronic neuropathic pain caused by nerve damage is a most common clinical symptom,
often accompanied by anxiety-and depression-like symptoms. Current treatments are very …

Peripheral nerve injury could lead to chronic neuropathic pain. Understanding
transcriptional changes induced by nerve injury could provide fundamental insights into the …

Background Mechanisms of neuropathic pain are not fully understood. Molecular changes in
spinal dorsal horn take part in the initiation and development of neuropathic pain. Methods …

Human and animal imaging studies demonstrated that chronic pain profoundly alters the
structure and the functionality of several brain regions. In this article, we conducted a …

Background Peripheral nerve injury can have long-term consequences including pain-
related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and …

Single-cell RNA sequencing (scRNA-seq) has allowed profiling cell types of the dorsal root
ganglia (DRG) and their transcriptional states in physiology and chronic pain. However, the …

The dorsal root ganglion (DRG) contains sensory neurons that innervate the surface of the
body and many visceral organs. Included amongst these neurons are nociceptors …

Background: The past decade has seen an abundance of transcriptional profiling studies of
preclinical models of persistent pain, predominantly employing microarray technology. In …