Inorganic arsenic: A non-genotoxic carcinogen

SM Cohen, A Chowdhury, LL Arnold - Journal of Environmental Sciences, 2016 - Elsevier
Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for
cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and …

Is ingested inorganic arsenic a “threshold” carcinogen?

CO Abernathy, WR Chappell, ME Meek… - Toxicological …, 1996 - academic.oup.com
Ingested inorganic arsenic (As) is known to be a human carcinogen. An intriguing question
is whether there is a threshold for the carcinogenic effects of As, ie, is there a level below …

Evaluation of the carcinogenicity of inorganic arsenic

SM Cohen, LL Arnold, BD Beck, AS Lewis… - Critical reviews in …, 2013 - Taylor & Francis
Inorganic arsenic (iAs) at high exposures is a human carcinogen, affecting mainly the
urinary bladder, lung and skin. We present an assessment of the mode of action (MOA) of …

Requirements for a biologically realistic cancer risk assessment for inorganic arsenic

HJ Clewell, PR Gentry, HA Barton… - … journal of toxicology, 1999 - journals.sagepub.com
A remarkable feature of the carcinogenicity of inorganic arsenic (As,) is the observation that
human exposures to Asi have been strongly associated with increases in skin, lung, and …

Arsenic and cancer: The still unanswered question

A Pelfrene - Journal of Toxicology and Environmental Health, Part …, 1976 - Taylor & Francis
For some 2,500 years, arsenic was considered an important element of pharmacopeias and
was praised for its medicinal qualities. However, an incidental link with cancer was …

Invited reviews: carcinogenic and systemic health effects associated with arsenic exposure—a critical review

PB Tchounwou, AK Patlolla… - Toxicologic …, 2003 - journals.sagepub.com
Arsenic and arsenic containing compounds are human carcinogens. Exposure to arsenic
occurs occupationally in several industries, including mining, pesticide, pharmaceutical …

Carcinogenicity, teratogenicity and mutagenicity of arsenic

A Leonard, RR Lauwerys - Mutation Research/Reviews in Genetic …, 1980 - Elsevier
Arsenic may be released into the environment through industrial processes and through the
generation of power from coal. It is also widely used in agriculture and was formerly used …

Carcinogenic risks of inorganic arsenic in perspective

DM Byrd, ML Roegner, JC Griffiths, SH Lamm… - International archives of …, 1996 - Springer
Induction of cancer by inorganic arsenic occurs inconsistently between species and
between routes of exposure, and it exhibits different dose-response relationships between …

Inorganic arsenic: a need and an opportunity to improve risk assessment.

WR Chappell, BD Beck, KG Brown… - Environmental …, 1997 - ehp.niehs.nih.gov
This paper presents views on the current status of (inorganic) arsenic risk assessment in the
United States and recommends research needed to set standards for drinking water. The …

Arsenic carcinogenesis in animals and in humans: mechanistic, experimental, and epidemiological evidence

PC Chan, J Huff - Journal of Environmental Science & Health Part …, 1997 - Taylor & Francis
Arsenic (As) commands a myriad and infamous past. From medicament to poison. From
home remedies and witchcraft to toxicant and carcinogen. Arsenic and its compounds occur …